If you find you are getting Windows cannot access the specified device, path, or file” stops me from running ANY exe on Win2k3 Server after installing IE8

Ensure that your intranet settings are on in IE8 if they are then this may help

From the workstations that can’t run the files, add the servers to the Trusted Zone – file://server
Then in the Security tab of IE Options, select the Trusted Site checkmark then hit the Custom level…button.
Scroll down to under Miscellaneous for “Launching applications and unsafe files” – set it to Enable